Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 11/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.44 |
| ▸ | STS | P08842 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3810121 | 0.84 | PDE4B (0.52) | CYP19A1PDE4BSTS | |
| SCHEMBL8064800 | 0.84 | HTT (0.52) | HDAC1HDAC6PDE4B | |
| SCHEMBL3805932 | 0.84 | PDE4B (0.58) | CYP19A1PDE4BSTS | |
| SCHEMBL8067067 | 0.84 | CYP19A1 (0.50) | CYP19A1PDE4BSTS | |
| SCHEMBL3805833 | 0.83 | HDAC1 (0.51) | CYP19A1HDAC1HDAC6STS | |
| SCHEMBL4322642 | 0.83 | CYP19A1 (0.55) | CYP19A1HDAC1HDAC6PDE4BSTS | |
| SCHEMBL4330785 | 0.82 | HDAC1 (0.49) | CYP19A1HDAC1HDAC6STS | |
| SCHEMBL4322192 | 0.82 | CYP19A1 (0.48) | CYP19A1PDE4BSTS | |
| SCHEMBL4323206 | 0.81 | CYP19A1 (0.49) | CYP19A1PDE4BSTS | |
| SCHEMBL3809178 | 0.81 | CYP19A1 (0.57) | CYP19A1STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |