Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.45 |
| ▸ | KAT7 | O95251 | 5/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 5/20 | 0.43 |
| ▸ | KAT6B | Q8WYB5 | 3/20 | 0.43 |
| ▸ | KAT5 | Q92993 | 2/20 | 0.43 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7904659 | 0.84 | CYP19A1 (0.47) | PDE4BHDAC1HDAC6 | |
| SCHEMBL7913026 | 0.80 | PDE4B (0.43) | HTTPDE4BPDE4D | |
| SCHEMBL4319471 | 0.79 | PDE4B (0.47) | HTTUSP2GAAMAPTMEN1 | |
| SCHEMBL8014205 | 0.78 | PDE4B (0.46) | HTTMAPTMEN1KMT2ATSHR | |
| SCHEMBL8067030 | 0.78 | PDE4D (0.49) | HTTMAPTMEN1KMT2ATSHR | |
| SCHEMBL8066867 | 0.78 | PDE4B (0.46) | HTTUSP2MAPTMEN1KMT2A | |
| SCHEMBL8066070 | 0.77 | HTT (0.57) | HTTUSP2MAPTKMT2ATSHR | |
| SCHEMBL8068535 | 0.77 | HDAC7 (0.49) | HTTMEN1KMT2APDE4BALDH1A1 | |
| SCHEMBL8053373 | 0.77 | POLB (0.46) | MAPTMEN1KMT2APDE4BALDH1A1 | |
| SCHEMBL8067341 | 0.76 | HTR1A (0.42) | MAPTPDE4BALDH1A1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |