Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.44 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.44 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.44 |
| ▸ | CBFB | Q13951 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7902882 | 0.83 | ALDH1A1 (0.51) | TDP1ALDH1A1SMN1; SMN2POLBHTT | |
| SCHEMBL973116 | 0.83 | TDP1 (0.54) | TDP1HDAC1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL17244480 | 0.82 | HDAC1 (0.58) | TDP1HDAC1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL11171029 | 0.80 | SMN1; SMN2 (0.69) | TDP1HDAC1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL7509092 | 0.78 | TDP1 (0.60) | TDP1HDAC1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL30442658 | 0.78 | TDP1 (0.60) | TDP1HDAC1ALDH1A1SMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL7516181 | 0.77 | TDP1 (0.58) | TDP1HDAC1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4055616 | 0.75 | TDP1 (0.57) | TDP1ALDH1A1SMN1; SMN2POLBHTT | |
| SCHEMBL30483162 | 0.75 | TDP1 (0.57) | TDP1ALDH1A1SMN1; SMN2POLBHTT | |
| SCHEMBL2081736 | 0.75 | TDP1 (0.57) | TDP1ALDH1A1SMN1; SMN2POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373634-B1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | MOCHIDA PHARM CO LTD (JP) | 2015-11-11 | — | — | EP | disclosed |
| WO-2010065717-A1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2010-06-10 | — | — | WO | disclosed |