Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656269 | 0.79 | MYC (0.54) | LMNANPSR1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL4555026 | 0.75 | LMNA (0.75) | LMNAKDRNPSR1SMN1; SMN2MAPT | |
| SCHEMBL6816290 | 0.74 | LMNA (0.65) | LMNAKDRNPSR1SMN1; SMN2MAPT | |
| SCHEMBL4555072 | 0.71 | LMNA (0.69) | LMNAKDRNPSR1SMN1; SMN2MAPT | |
| SCHEMBL4555515 | 0.70 | LMNA (0.68) | LMNAKDRNPSR1MAPTPDK1 | |
| SCHEMBL6816279 | 0.70 | LMNA (0.60) | LMNAKDRNPSR1MAPTMAPK1 | |
| SCHEMBL29494977 | 0.69 | LMNA (0.66) | LMNAKDRNPSR1SMN1; SMN2MAPT | |
| SCHEMBL22092638 | 0.69 | LMNA (0.66) | LMNAKDRNPSR1SMN1; SMN2MAPT | |
| SCHEMBL6815784 | 0.68 | LMNA (0.64) | LMNAKDRNPSR1MAPTPDK1 | |
| SCHEMBL18196961 | 0.68 | LMNA (0.64) | LMNAKDRNPSR1MAPTPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207715-B1 | USEFUL IN THERAPY OF DISEASES ASSOCIATED WITH HERPES VIRUSES INCLUDING HUMAN CYTOMEGALOVIRUS, HERPES SIMPLEX VIRUSES, EPSTEIN-BARR VIRUS, VARICELLA-ZOSTER VIRUS, HUMAN HERPESVIRUSES-6 AND -7, AND KAPOSI HERPES VIRUS | AMERICAN HOME PRODUCTS CORPORATION | 2001-03-27 | — | — | US | disclosed |