SCHEMBL7905266

SCHEMBL7905266

COc1ccc(N=Nc2c(S(=O)(=O)O)cc3cc(NC(=O)c4cc(OC)cc(OC)c4)ccc3c2O)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRMT1 Q99873 3/20 0.58
PRMT3 O60678 1/20 0.58
EP300 Q09472 1/20 0.58
PRMT6 Q96LA8 1/20 0.58
ENPP2 Q13822 9/20 0.57
CARM1 Q86X55 1/20 0.56
CD40 P25942 1/20 0.55
CD40LG P29965 1/20 0.55
CASP3 P42574 1/20 0.48
SENP8 Q96LD8 1/20 0.48
SENP7 Q9BQF6 1/20 0.48
SENP6 Q9GZR1 1/20 0.48
CA2 P00918 1/20 0.46
CA3 P07451 1/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
ALDH1A1 P00352 1/20 0.45
TP53 P04637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7905259 1.00 PRMT1 (0.58) PRMT1PRMT3EP300PRMT6ENPP2
SCHEMBL7906557 0.93 PRMT1 (0.66) PRMT1PRMT3EP300PRMT6ENPP2
SCHEMBL7906615 0.93 PRMT1 (0.66) PRMT1PRMT3EP300PRMT6ENPP2
SCHEMBL7899067 0.89 PRMT1 (0.55) PRMT1PRMT3EP300PRMT6ENPP2
SCHEMBL7898901 0.89 PRMT1 (0.55) PRMT1PRMT3EP300PRMT6ENPP2
SCHEMBL7898906 0.89 PRMT1 (0.55) PRMT1PRMT3EP300PRMT6ENPP2
SCHEMBL7907937 0.89 PRMT1 (0.55) PRMT1PRMT3EP300PRMT6ENPP2
SCHEMBL7906632 0.89 PRMT1 (0.53) PRMT1PRMT3EP300PRMT6ENPP2
SCHEMBL7907398 0.86 PRMT1 (0.58) PRMT1PRMT3EP300PRMT6ENPP2
SCHEMBL17540333 0.83 PRMT3 (0.74) PRMT1PRMT3EP300PRMT6ENPP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6200963-B1 USEFUL AS FEMALE AND MALE CONTRACEPTIVE AGENTS AMERICAN HOME PRODUCTS CORPORATION 2001-03-13 US claimed
WO-2000058276-A1 7-AMINO-4-HYDROXY-3-(4-METHOXY-PHENYLAZO)-NAPHTHALENE-2-SULFONIC ACID DERIVATIVES AS FSH ANTAGONISTS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-10-05 WO claimed
US-6200963-B1 USEFUL AS FEMALE AND MALE CONTRACEPTIVE AGENTS AMERICAN HOME PRODUCTS CORPORATION 2001-03-13 US disclosed
WO-2000058276-A1 7-AMINO-4-HYDROXY-3-(4-METHOXY-PHENYLAZO)-NAPHTHALENE-2-SULFONIC ACID DERIVATIVES AS FSH ANTAGONISTS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-10-05 WO disclosed