Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25131500 | 0.79 | TACR1 (0.41) | TACR1TSHRNPSR1MEN1KMT2A | |
| SCHEMBL25131487 | 0.77 | TACR1 (0.40) | TACR1TSHRNPSR1MEN1KMT2A | |
| SCHEMBL20512123 | 0.74 | TACR1 (0.40) | TACR1TSHRNPSR1MEN1KMT2A | |
| SCHEMBL27674725 | 0.73 | TSHR (0.47) | TACR1TSHRNPSR1MEN1KMT2A | |
| SCHEMBL28306256 | 0.72 | TSHR (0.54) | TACR1TSHRSLC6A4 | |
| SCHEMBL25131484 | 0.71 | MAPT (0.36) | TACR1TSHRNPSR1MAOBALDH1A1 | |
| SCHEMBL599239 | 0.70 | TSHR (0.47) | TACR1TSHRLMNAMMP2MMP3 | |
| Oxirane SCHEMBL3317346 | 0.69 | TSHR (0.75) | TACR1TSHRNPSR1MEN1KMT2A | |
| SCHEMBL15105750 | 0.69 | TACR1 (0.46) | TACR1TSHRKMT2AGRM5ALDH1A1 | |
| SCHEMBL2221074 | 0.68 | TSHR (0.48) | TACR1TSHRNPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616080-A1 | 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | Gilead Sciences, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012037038-A1 | 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2012-03-22 | — | — | WO | disclosed |