Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.37 |
| ▸ | PGR | P06401 | 2/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467918 | 0.84 | ALDH1A1 (0.43) | SMN1; SMN2LMNAKDM4EALDH1A1HTT | |
| SCHEMBL3466953 | 0.82 | CYP19A1 (0.38) | SMN1; SMN2ALDH1A1HTTMAPTGAA | |
| SCHEMBL3466417 | 0.79 | ALDH1A1 (0.40) | SMN1; SMN2LMNAKDM4EALDH1A1HTT | |
| SCHEMBL3466921 | 0.78 | CNR1 (0.40) | SMN1; SMN2ALDH1A1HTTMAPTMEN1 | |
| SCHEMBL7918235 | 0.77 | ENPP1 (0.40) | SMN1; SMN2LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL3467808 | 0.77 | PPID (0.41) | SMN1; SMN2LMNAKDM4EALDH1A1HTT | |
| SCHEMBL16158918 | 0.76 | SMN1; SMN2 (0.40) | SMN1; SMN2LMNAKDM4EALDH1A1HTT | |
| SCHEMBL3467147 | 0.75 | ALDH1A1 (0.40) | SMN1; SMN2LMNAKDM4EALDH1A1HTT | |
| SCHEMBL3785842 | 0.75 | HTT (0.41) | SMN1; SMN2LMNAALDH1A1HTTACLY | |
| SCHEMBL4326854 | 0.75 | PDE4D (0.48) | SMN1; SMN2KDM4EALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |