Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.57 |
| ▸ | MTOR | P42345 | 5/20 | 0.57 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL381071 | 0.73 | PIK3CA (1.00) | PIK3CAMTOR | |
| SCHEMBL407547 | 0.58 | PIK3CA (1.00) | PIK3CAMTOR | |
| SCHEMBL380724 | 0.56 | PIK3CA (0.72) | PIK3CAMTORPIK3C3 | |
| SCHEMBL21627244 | 0.51 | PDE3B (0.55) | — | |
| SCHEMBL20779246 | 0.49 | RAB9A (0.47) | — | |
| SCHEMBL16983101 | 0.49 | ROCK1 (0.46) | — | |
| SCHEMBL3037991 | 0.49 | HTT (0.52) | — | |
| SCHEMBL17858704 | 0.49 | PIK3CA (0.47) | PIK3CAMTORPIK3C3 | |
| SCHEMBL24857385 | 0.49 | NTRK1 (0.77) | PIK3C3 | |
| SCHEMBL22071838 | 0.49 | PIK3CA (0.41) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010108074-A2 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2010-09-23 | — | — | WO | disclosed |