Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.55 |
| ▸ | IL2 | P60568 | 4/20 | 0.55 |
| ▸ | MAP3K11 | Q16584 | 6/20 | 0.50 |
| ▸ | TNIK | Q9UKE5 | 9/20 | 0.48 |
| ▸ | IKBKB | O14920 | 2/20 | 0.47 |
| ▸ | CHUK | O15111 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | INSR | P06213 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | SGK1 | O00141 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26175663 | 0.89 | MAP4K1 (0.63) | MAP4K1IL2MAP3K11TNIKIKBKB | |
| SCHEMBL26178169 | 0.88 | MAP4K1 (0.53) | MAP4K1IL2MAP3K11TNIKDYRK1A | |
| SCHEMBL30399294 | 0.85 | MAP4K1 (0.73) | MAP4K1IL2MAP3K11TNIKIKBKB | |
| SCHEMBL26175624 | 0.85 | MAP4K1 (0.73) | MAP4K1IL2MAP3K11TNIKIKBKB | |
| SCHEMBL26175671 | 0.84 | MAP4K1 (0.58) | MAP4K1IL2MAP3K11TNIKIKBKB | |
| SCHEMBL26175268 | 0.83 | TNIK (0.62) | MAP4K1IL2TNIK | |
| SCHEMBL26178157 | 0.83 | MAP4K1 (0.54) | MAP4K1IL2MAP3K11TNIKLRRK2 | |
| SCHEMBL7907723 | 0.82 | MAP3K11 (0.73) | MAP4K1MAP3K11TNIKIKBKBCHUK | |
| SCHEMBL26175668 | 0.82 | MAP4K1 (0.52) | MAP4K1IL2MAP3K11TNIKIKBKB | |
| SCHEMBL7906295 | 0.82 | MAP4K1 (0.66) | MAP4K1IL2MAP3K11TNIKNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |