Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.66 |
| ▸ | IL2 | P60568 | 5/20 | 0.66 |
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 4/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12066047 | 0.83 | MAP3K11 (0.67) | MAP4K1MAP3K11NTRK1TNIK | |
| SCHEMBL7906293 | 0.82 | MAP4K1 (0.55) | MAP4K1IL2MAP3K11NTRK1DYRK1A | |
| SCHEMBL7908989 | 0.81 | MAP3K11 (0.63) | MAP3K11NTRK1DYRK1ATNIKPIK3CA | |
| SCHEMBL7907491 | 0.81 | AXL (0.64) | MAP3K11NTRK1TNIK | |
| SCHEMBL7910407 | 0.81 | MAP3K11 (0.47) | MAP4K1MAP3K11NTRK1DYRK1ATNIK | |
| SCHEMBL7906551 | 0.80 | KIT (0.57) | MAP3K11NTRK1DYRK1ATNIKPIK3CA | |
| SCHEMBL7905041 | 0.80 | NTRK1 (0.63) | MAP3K11NTRK1DYRK1ATNIKPIK3CA | |
| SCHEMBL30400140 | 0.79 | MAP4K1 (0.64) | MAP4K1IL2MAP3K11TNIK | |
| SCHEMBL26178075 | 0.79 | MAP4K1 (0.64) | MAP4K1IL2MAP3K11TNIK | |
| SCHEMBL723387 | 0.79 | MAP3K11 (1.00) | MAP4K1IL2MAP3K11NTRK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |