Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10748579 | 0.83 | CYP3A4 (0.39) | CYP3A4TSHRMAPK1TDP1 | |
| SCHEMBL9938916 | 0.82 | KEAP1 (0.44) | KEAP1NFE2L2CYP11B1CYP11B2 | |
| SCHEMBL29448446 | 0.82 | KEAP1 (0.44) | KEAP1NFE2L2CYP11B1CYP11B2 | |
| SCHEMBL29260193 | 0.77 | KEAP1 (0.56) | KEAP1NFE2L2TDP1 | |
| SCHEMBL8339603 | 0.76 | TSHR (0.39) | CYP3A4TSHRMAPK1TDP1 | |
| SCHEMBL8778861 | 0.73 | CYP3A4 (0.32) | CYP3A4TSHRMAPK1TDP1 | |
| SCHEMBL6222738 | 0.70 | KEAP1 (0.50) | KEAP1NFE2L2TDP1CYP11B1CYP11B2 | |
| SCHEMBL7057611 | 0.69 | TSHR (0.46) | CYP3A4TSHRMAPK1TDP1 | |
| SCHEMBL30409600 | 0.67 | CYP3A4 (0.33) | CYP3A4TSHRMAPK1TDP1 | |
| SCHEMBL8975115 | 0.67 | CYP3A4 (0.33) | CYP3A4TSHRMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187376-A2 | 6,7-Disubstituted 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids | BAYER AG (DE) | 1986-07-16 | — | — | EP | claimed |
| US-6197964-B1 | CHLORINATION USING BASIC CATALYST; DESALTING, HYDROLYSIS | BAYER AKTIENGESELLSCHAFT (DE) | 2001-03-06 | — | — | US | disclosed |
| EP-0973745-A1 | METHOD FOR THE PRODUCTION OF 2,6-DICHLORO-5-FLUORONICOTINONITRILE AND THE CHEMICAL COMPOUND 3-CYANO-2-HYDROXY-5-FLUOROPYRIDE-6-ONE-MONOSODIUM SALT AND ITS TAUTOMERS | BAYER AG (DE) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998043958-A1 | METHOD FOR THE PRODUCTION OF 2,6-DICHLORO-5-FLUORONICOTINONITRILE AND THE CHEMICAL COMPOUND 3-CYANO-2-HYDROXY-5-FLUOROPYRIDE-6-ONE-MONOSODIUM SALT AND ITS TAUTOMERS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-10-08 | — | — | WO | disclosed |
| EP-0700903-B1 | PROCESS FOR PRODUCING CYANOPYRIDINE | IHARA CHEMICAL IND CO (JP) | 1997-11-12 | — | — | EP | disclosed |
| US-5675012-A | REACTING AMMONIUM HALIDE WITH TRICHLOROMETHYLPYRIDINE IN PRESENCE OF A COPPER AND ZINC COMPOUND | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 1997-10-07 | — | — | US | disclosed |
| EP-0700903-A1 | PROCESS FOR PRODUCING CYANOPYRIDINE | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 1996-03-13 | — | — | EP | disclosed |
| EP-0187376-B1 | 6,7-DISUBSTITUTED 1-CYCLOPROPYL-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS | BAYER AG (DE) | 1992-05-13 | — | — | EP | disclosed |
| EP-0333020-A2 | Process for the preparation of substituted pyridines | ABBOTT LABORATORIES (US) | 1989-09-20 | — | — | EP | disclosed |
| US-4840954-A | BACTERICIDE | BAYER AKTIENGESELLSCHAFT (DE) | 1989-06-20 | — | — | US | disclosed |
| EP-0187376-A2 | 6,7-Disubstituted 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids | BAYER AG (DE) | 1986-07-16 | — | — | EP | disclosed |