Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2750773 | 0.88 | PDE10A (0.57) | PDE10AHTTNR3C2ALDH1A1ELOVL1 | |
| SCHEMBL2498709 | 0.88 | PDE10A (0.55) | PDE10AHTTNR3C2ALDH1A1ELOVL1 | |
| SCHEMBL3505270 | 0.88 | PDE10A (0.55) | PDE10AHTTNR3C2ALDH1A1ELOVL1 | |
| SCHEMBL14315130 | 0.86 | PDE10A (0.62) | PDE10AHTTALDH1A1PKM | |
| SCHEMBL2503833 | 0.85 | PDE10A (0.52) | PDE10AHTTALDH1A1ELOVL1 | |
| SCHEMBL2476580 | 0.85 | PDE10A (0.52) | PDE10AHTTNR3C2ALDH1A1ELOVL1 | |
| SCHEMBL7908353 | 0.85 | PDE10A (0.68) | PDE10AHTTNR3C2ALDH1A1PKM | |
| SCHEMBL3507069 | 0.85 | PDE10A (0.61) | PDE10AHTTNR3C2ALDH1A1ELOVL1 | |
| SCHEMBL7911489 | 0.84 | PDE10A (0.58) | PDE10AHTTNR3C2ALDH1A1 | |
| SCHEMBL2476174 | 0.84 | PDE10A (0.50) | PDE10AHTTNR3C2ALDH1A1ELOVL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373641-B1 | PYRIDAZINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-12-19 | — | — | EP | disclosed |
| WO-2010063610-A1 | PYRIDAZINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-10 | — | — | WO | disclosed |