Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2749209 | 0.93 | PDE10A (0.77) | PDE10AKDM4EPOLBNR3C2NOTUM | |
| SCHEMBL14315130 | 0.90 | PDE10A (0.62) | PDE10APOLBPKMALDH1A1CYP1A2 | |
| SCHEMBL2505485 | 0.89 | PDE10A (0.70) | PDE10AKDM4EPOLBNR3C2NOTUM | |
| SCHEMBL518641 | 0.89 | PDE10A (0.70) | PDE10AKDM4EPOLBNR3C2NOTUM | |
| SCHEMBL7911489 | 0.88 | PDE10A (0.58) | PDE10AKDM4ENR3C2ALDH1A1MAPK14 | |
| SCHEMBL2750293 | 0.87 | PDE10A (0.72) | PDE10AKDM4EPOLBNR3C2NOTUM | |
| SCHEMBL3503982 | 0.86 | PDE10A (0.68) | PDE10AKDM4EPOLBNR3C2NOTUM | |
| SCHEMBL3503172 | 0.86 | PDE10A (0.70) | PDE10AKDM4EPOLBNR3C2NOTUM | |
| SCHEMBL7906405 | 0.85 | PDE10A (0.54) | PDE10ANR3C2PKMALDH1A1HTT | |
| SCHEMBL3506101 | 0.84 | PDE10A (0.66) | PDE10AKDM4EPOLBNR3C2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373641-B1 | PYRIDAZINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-12-19 | — | — | EP | disclosed |
| WO-2010063610-A1 | PYRIDAZINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-10 | — | — | WO | disclosed |