Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.53 |
| ▸ | NQO1 | P15559 | 9/20 | 0.50 |
| ▸ | TOP1 | P11387 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7912659 | 0.85 | TOP2A (0.71) | TOP2ANQO1TOP1CYP2C9CRHBP | |
| SCHEMBL7896858 | 0.85 | TOP2A (0.71) | TOP2ANQO1TOP1CYP2C9CRHBP | |
| SCHEMBL7906511 | 0.85 | TOP2A (0.61) | TOP2ANQO1TOP1CYP2C9CRHBP | |
| SCHEMBL7907150 | 0.83 | NQO1 (0.73) | NQO1TOP1CYP2C9CRHBPCASP7 | |
| SCHEMBL7910932 | 0.73 | TOP2A (0.45) | TOP2ANQO1TOP1CYP2C9CRHBP | |
| SCHEMBL4385323 | 0.70 | NQO1 (1.00) | NQO1TOP1CYP2C9CRHBPCASP7 | |
| SCHEMBL25662445 | 0.69 | NQO1 (0.62) | NQO1TOP1CYP2C9CRHBPCASP7 | |
| SCHEMBL25660794 | 0.67 | NQO1 (0.60) | NQO1TOP1CYP2C9CRHBPCASP7 | |
| SCHEMBL7899682 | 0.67 | NQO1 (0.86) | NQO1TOP1CYP2C9CRHBPCASP7 | |
| SCHEMBL4390609 | 0.67 | NQO1 (1.00) | NQO1TOP1CYP2C9CRHBPCASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010075280-A2 | COUMARIN-BASED COMPOUNDS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2010-07-01 | — | — | WO | disclosed |