Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.71 |
| ▸ | NQO1 | P15559 | 10/20 | 0.56 |
| ▸ | TOP1 | P11387 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | GALK1 | P51570 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7906511 | 0.90 | TOP2A (0.61) | TOP2ANQO1TOP1CYP2C9CRHBP | |
| SCHEMBL7912659 | 0.90 | TOP2A (0.71) | TOP2ANQO1TOP1CYP2C9CRHBP | |
| SCHEMBL7907113 | 0.85 | TOP2A (0.53) | TOP2ANQO1TOP1CYP2C9CRHBP | |
| SCHEMBL12028810 | 0.81 | NQO1 (0.86) | TOP2ANQO1TOP1CYP2C9CRHBP | |
| SCHEMBL7906071 | 0.81 | TOP1 (0.43) | TOP2ATOP1MEN1KMT2A | |
| SCHEMBL7910932 | 0.75 | TOP2A (0.45) | TOP2ANQO1TOP1CYP2C9CRHBP | |
| SCHEMBL4385323 | 0.74 | NQO1 (1.00) | NQO1TOP1CYP2C9CRHBPCASP7 | |
| SCHEMBL7362123 | 0.72 | NQO1 (0.64) | TOP2ANQO1TOP1CYP2C9CRHBP | |
| SCHEMBL14172083 | 0.71 | NQO1 (1.00) | NQO1TOP1CYP2C9CRHBPCASP7 | |
| SCHEMBL7896856 | 0.70 | NQO1 (1.00) | NQO1TOP1CYP2C9CRHBPCASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010075280-A2 | COUMARIN-BASED COMPOUNDS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2010-07-01 | — | — | WO | disclosed |