Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL595243 | 0.89 | ATM (0.69) | POLBATMKMT2AMEN1CYP1A2 | |
| SCHEMBL17562151 | 0.78 | KMT2A (0.71) | POLBATMKMT2AMEN1CYP1A2 | |
| SCHEMBL2736397 | 0.77 | ATM (0.71) | POLBATMKMT2AMEN1CYP1A2 | |
| SCHEMBL7720566 | 0.76 | ATM (0.56) | ATMKMT2AMEN1LMNAUSP2 | |
| SCHEMBL2736392 | 0.76 | ATM (0.66) | POLBATMKMT2AMEN1CYP1A2 | |
| SCHEMBL11129976 | 0.75 | ATM (0.76) | ATMKMT2AMEN1LMNAUSP2 | |
| SCHEMBL1419881 | 0.75 | CYP1A2 (0.55) | POLBATMKMT2AMEN1CYP1A2 | |
| SCHEMBL6866118 | 0.75 | POLB (0.67) | POLBKMT2AMEN1MAPTNPSR1 | |
| SCHEMBL29171698 | 0.74 | KMT2A (0.48) | POLBATMKMT2AMEN1CYP1A2 | |
| SCHEMBL29171700 | 0.74 | KMT2A (0.48) | POLBATMKMT2AMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194590-B1 | PREPARING SUBSTITUTED BENZOFURAN-3-ONES BY REACTING SALICYLIC ACID ETHER COMPOUND WITH STRONG BASE IN INERT GAS AND/OR IN PRESENCE OF DILUENT; REACTING BENZOFURANONECARBOXYIC ACID ESTER WITH POTASSIUM HYDROXIDE AND THEN ACID ACID | BAYER AKTIENGESELLSCHAFT (DE) | 2001-02-27 | — | — | US | disclosed |