Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975724 | 0.74 | GNRHR (0.36) | GNRHR | |
| SCHEMBL8695357 | 0.70 | HTR1D (0.44) | GNRHR | |
| SCHEMBL7905654 | 0.70 | CYP19A1 (0.53) | — | |
| SCHEMBL7912408 | 0.69 | CYP1A2 (0.66) | GNRHR | |
| SCHEMBL6982096 | 0.69 | MAPT (0.46) | — | |
| SCHEMBL7995810 | 0.69 | GNRHR (0.54) | GNRHR | |
| Hydrochloric Acid SCHEMBL8699219 | 0.69 | MAPT (0.45) | — | |
| SCHEMBL6982851 | 0.67 | KDM4E (0.55) | GNRHR | |
| SCHEMBL6983816 | 0.67 | CXCR2 (0.49) | — | |
| SCHEMBL14006550 | 0.66 | GNRHR (0.65) | GNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197975-B1 | 7-AZABICYCLO(2.2.1)HEPTANE-7-CARBONYL-SUBSTITUTED 2-PHENYLINDOLE DERIVATIVES; SEXUAL DISORDERS; ANTICARCINOGENIC AGENTS | MERCK & CO. , INC. | 2001-03-06 | — | — | US | disclosed |
| EP-0882040-A4 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 1999-02-10 | — | — | EP | disclosed |
| EP-0882040-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997021707-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1997-06-19 | — | — | WO | disclosed |