SCHEMBL7907475

SCHEMBL7907475

COc1ccc([C@H]2CCOC2=O)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 1/20 0.50
CRBN Q96SW2 1/20 0.50
CYP19A1 P11511 2/20 0.49
ALOX15 P16050 1/20 0.47
ALOX12 P18054 1/20 0.47
ALDH1A1 P00352 5/20 0.46
KMT2A Q03164 2/20 0.45
MAPT P10636 2/20 0.45
HPGD P15428 2/20 0.45
MEN1 O00255 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.42
KDM4E B2RXH2 1/20 0.42
MAP2K3 P46734 1/20 0.42
EGFR P00533 1/20 0.42
POLB P06746 1/20 0.42
RECQL P46063 1/20 0.42
NPC1 O15118 1/20 0.41
TP53 P04637 1/20 0.41
MAOA P21397 1/20 0.41
PTGS2 P35354 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2303850 1.00 DDB1 (0.50) DDB1CRBNCYP19A1ALOX15ALOX12
SCHEMBL28722327 0.81 DDB1 (0.55) DDB1CRBNCYP19A1ALDH1A1
SCHEMBL576857 0.80 CYP19A1 (0.45) CYP19A1ALDH1A1KMT2AMAPTHPGD
SCHEMBL8729044 0.79 ACHE (0.48) ALDH1A1RAB9A
SCHEMBL7905996 0.79 ACHE (0.48) ALDH1A1RAB9A
SCHEMBL28721861 0.79 PRKDC (0.40)
SCHEMBL12951798 0.77 DDB1 (0.48) DDB1CRBNCYP19A1ALOX15ALOX12
SCHEMBL21470639 0.77 DDB1 (0.55) DDB1CRBNCYP19A1ALOX15ALOX12
SCHEMBL1533278 0.77 CYP19A1 (0.45) CYP19A1ALDH1A1SMN1; SMN2
SCHEMBL10393997 0.77 TP53 (0.42) CYP19A1ALDH1A1KMT2AMEN1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6207862-B1 PRECURSORS ARE CHIRAL 4-HYDROXYCARBOXAMIDES, 4-HYDROXYHYDROXAMIC ACIDS, OR 4-HYDROXYHYDRAZIDES PRODUCED FROM GAMMA-LACTONES, WHICH IN TURN ARE DERIVED FROM 1,4-DIOLS BY STEREOSELECTIVE OXIDATION, BIOCATALYTICS, INC. 2001-03-27 US disclosed
WO-1999032649-A1 METHODS AND PRECURSORS FOR THE PRODUCTION OF CHIRAL 1,3-AMINOALCOHOLS BIOCATALYTICS, INC. (US) 1999-07-01 WO disclosed
US-5916786-A Method for the production of chiral 1,3-aminoalcohols BIOCATALYTICS, INC. (US) 1999-06-29 US disclosed