Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 6/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 3/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7907191 | 0.86 | HSD11B1 (0.42) | HSD11B1GRM5BACE1KCNH2APP | |
| SCHEMBL7903362 | 0.82 | GRM5 (0.66) | GRM5KCNH2 | |
| SCHEMBL7906315 | 0.81 | NPC1 (0.56) | GRM5LRRK2BACE1KCNH2BACE2 | |
| SCHEMBL7904772 | 0.81 | GRM5 (0.46) | GRM5KCNH2 | |
| SCHEMBL7899803 | 0.81 | GRM5 (0.67) | GRM5 | |
| SCHEMBL7909378 | 0.81 | LRRK2 (0.52) | GRM5LRRK2BACE1KCNH2BACE2 | |
| SCHEMBL7909685 | 0.81 | CYP3A4 (0.59) | GRM5 | |
| SCHEMBL7904713 | 0.80 | TMPRSS4 (0.55) | GRM5BACE1KCNH2 | |
| SCHEMBL7900427 | 0.80 | KMT2A (0.54) | LRRK2 | |
| SCHEMBL13148059 | 0.79 | GRM5 (0.45) | GRM5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100050-A1 | PYRIDINE-2-YL-CARBOXYLIC ACID AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-10 | — | — | WO | disclosed |
| US-20100227887-A1 | PYRIDINE-2-YL CARBOXYLIC ACID AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227887-A1 | PYRIDINE-2-YL CARBOXYLIC ACID AMIDES | GRM2, GRM1, GRM3 | HSD11B1 4419/4885GRM5 6/4885LRRK2 1918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.