Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.69 |
| ▸ | RAB9A | P51151 | 8/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.69 |
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | PKM | P14618 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | IL6 | P05231 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29236673 | 0.84 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2NPSR1GAA | |
| SCHEMBL3949035 | 0.83 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2NPSR1GAA | |
| SCHEMBL25292085 | 0.83 | SIRT7 (0.53) | NPC1RAB9ASMN1; SMN2NPSR1GAA | |
| SCHEMBL25788974 | 0.83 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2NPSR1GAA | |
| SCHEMBL25247545 | 0.83 | IL6 (0.51) | NPC1RAB9ASMN1; SMN2NPSR1GAA | |
| SCHEMBL25242316 | 0.83 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2NPSR1GAA | |
| SCHEMBL29972698 | 0.83 | NPC1 (0.75) | NPC1RAB9ASMN1; SMN2NPSR1GAA | |
| SCHEMBL1699100 | 0.83 | NPC1 (0.75) | NPC1RAB9ASMN1; SMN2NPSR1GAA | |
| SCHEMBL2658434 | 0.82 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2NPSR1GAA | |
| SCHEMBL18235580 | 0.82 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2NPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6222044-B1 | REACTING AN AROMATIC ALDEHYDE WITH HYDROXYLAMINE TO FORM AN AROMATIC ALDEHYDE OXIME, HALOGENATING OXIME TO FORM AROMATIC HYDROXAMOYL HALIDE, AND REACTING WITH AROMATIC AMINE COMPOUNDS TO FORM BENZOXAZOLE, BENZOTHIAXOLE, BENZIMIDAZOLES | THE DOW CHEMICAL COMPANY | 2001-04-24 | — | — | US | disclosed |
| EP-0820447-B1 | PROCESS FOR MAKING 2-ARYL BENZ(OX, THI, IMID)AZOLES AND 2-AMINOARYL AMINOBENZ(OX, THI, IMID)AZOLES | DOW CHEMICAL CO (US) | 2000-08-23 | — | — | EP | disclosed |
| EP-0820447-A1 | PROCESS FOR MAKING 2-ARYL BENZ(OX, THI, IMID)AZOLES AND 2-AMINOARYL AMINOBENZ(OX, THI, IMID)AZOLES | THE DOW CHEMICAL COMPANY (US) | 1998-01-28 | — | — | EP | disclosed |
| US-5567843-A | Process for making 2-aryl benz (ox, thi, imid)azoles and 2-aminoaryl aminobenz(ox, thi, imid)azoles | THE DOW CHEMICAL COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| WO-1996029319-A1 | PROCESS FOR MAKING 2-ARYL BENZ(OX, THI, IMID)AZOLES AND 2-AMINOARYL AMINOBENZ(OX, THI, IMID)AZOLES | THE DOW CHEMICAL COMPANY (US) | 1996-09-26 | — | — | WO | disclosed |