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Sugi Predict / Compounds / SCHEMBL7908428

SCHEMBL7908428

SCHEMBL7908428

CCCc1nc(CO)c(C(=O)OCOC(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2C2(C(c3ccccc3)(c3ccccc3)c3ccccc3)N=NN=N2)cc1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ AGTR1 P30556 8/20 0.46
▸ AGTR2 P50052 8/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8860955 0.95 AGTR1 (0.45) AGTR1AGTR2
SCHEMBL7303268 0.91 AGTR1 (0.49) AGTR1AGTR2
SCHEMBL7297184 0.91 AGTR1 (0.50) AGTR1AGTR2
SCHEMBL7306984 0.90 AGTR1 (0.41) AGTR1AGTR2
SCHEMBL7304485 0.87 AGTR1 (0.53) AGTR1
SCHEMBL7887868 0.86 AGTR1 (0.36) AGTR1AGTR2
SCHEMBL7299323 0.85 AGTR1 (0.46) AGTR1AGTR2
SCHEMBL7302847 0.85 AGTR1 (0.43) AGTR1AGTR2
SCHEMBL7887819 0.84 AGTR1 (0.40) AGTR1AGTR2
SCHEMBL7310118 0.83 AGTR1 (0.54) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0545912-B1 1-Biphenylmethylimidazole derivatives, their preparation and their therapeutic use SANKYO CO (JP) 2001-04-25 — — EP disclosed
US-5646171-A HYPOTENSIVE AGENTS SANKYO COMPANY, LIMITED (JP) 1997-07-08 — — US disclosed
US-5616599-A HYPOTENSIVE AGENTS FOR CARDIOVASCULAR DISORDER SANKYO COMPANY, LIMITED (JP) 1997-04-01 — — US disclosed