Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 13/20 | 0.40 |
| ▸ | ALB | P02768 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TGM2 | P21980 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7901824 | 0.86 | FOLH1 (0.42) | FOLH1ALBSMN1; SMN2TGM2 | |
| SCHEMBL7909550 | 0.84 | FOLH1 (0.38) | FOLH1ALBSMN1; SMN2TGM2 | |
| SCHEMBL7915411 | 0.79 | FOLH1 (0.39) | FOLH1ALB | |
| SCHEMBL7901699 | 0.79 | FOLH1 (0.49) | FOLH1ALBSMN1; SMN2EPHX2 | |
| SCHEMBL7908779 | 0.78 | DPP7 (0.34) | — | |
| SCHEMBL7909235 | 0.77 | FOLH1 (0.43) | FOLH1SMN1; SMN2 | |
| SCHEMBL7909229 | 0.77 | FOLH1 (0.43) | FOLH1SMN1; SMN2 | |
| SCHEMBL3438496 | 0.72 | FOLH1 (0.62) | FOLH1ALBSMN1; SMN2 | |
| SCHEMBL7908658 | 0.71 | FOLH1 (0.48) | FOLH1ALBSMN1; SMN2 | |
| SCHEMBL7908703 | 0.71 | FOLH1 (0.48) | FOLH1ALBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207708-B1 | FOR THERAPY AND PROPHYLAXIS OF AUTOIMMUNE AND/OR INFLAMMATORY CONDITIONS AFFECTING THE JOINTS SUCH AS ARTHRITIS, AND INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, | G. D. SEARLE & COMPANY | 2001-03-27 | — | — | US | disclosed |
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | disclosed |