Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 9/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | ALB | P02768 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7901824 | 0.82 | FOLH1 (0.42) | FOLH1SIRT1ALB | |
| SCHEMBL7915415 | 0.81 | DPP8 (0.37) | MMP2TDP1SLC6A2SLC6A3KMT2A | |
| SCHEMBL7909550 | 0.80 | FOLH1 (0.38) | FOLH1SIRT2SIRT1MMP2MMP9 | |
| SCHEMBL7908773 | 0.79 | FOLH1 (0.40) | FOLH1ALB | |
| SCHEMBL7908736 | 0.78 | FOLH1 (0.41) | FOLH1SIRT2SIRT1 | |
| SCHEMBL7908742 | 0.78 | FOLH1 (0.41) | FOLH1SIRT2SIRT1 | |
| SCHEMBL7901699 | 0.72 | FOLH1 (0.49) | FOLH1ALB | |
| SCHEMBL7224728 | 0.72 | FOLH1 (0.43) | FOLH1SIRT2SIRT1TDP1 | |
| SCHEMBL15249558 | 0.70 | FOLH1 (0.71) | FOLH1SIRT2SIRT1MMP2MMP9 | |
| SCHEMBL7225511 | 0.69 | TNF (0.41) | TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207708-B1 | FOR THERAPY AND PROPHYLAXIS OF AUTOIMMUNE AND/OR INFLAMMATORY CONDITIONS AFFECTING THE JOINTS SUCH AS ARTHRITIS, AND INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, | G. D. SEARLE & COMPANY | 2001-03-27 | — | — | US | disclosed |
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | disclosed |