Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.49 |
| ▸ | PDE4A | P27815 | 11/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314291 | 0.90 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7321658 | 0.89 | PDE4A (0.53) | PDE5APDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6510627 | 0.89 | PDE4A (0.53) | PDE5APDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7323469 | 0.88 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7323473 | 0.88 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL8291061 | 0.87 | PDE4A (0.48) | PDE5APDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7323453 | 0.87 | PDE4A (0.48) | PDE5APDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7316508 | 0.85 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7316509 | 0.85 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7910865 | 0.84 | PDE4A (0.53) | PDE5APDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626939-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2001-11-07 | — | — | EP | disclosed |