Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 1/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | SLC1A5 | Q15758 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7909573 | 1.00 | L3MBTL1 (0.41) | L3MBTL1ALPIPKMPTGS1XIAP | |
| SCHEMBL7911979 | 0.84 | L3MBTL1 (0.44) | L3MBTL1ALPIPKMPTGS1XIAP | |
| Hydrochloric Acid SCHEMBL8201921 | 0.83 | L3MBTL1 (0.43) | L3MBTL1ALPIPKMPTGS1XIAP | |
| SCHEMBL8205413 | 0.76 | SLC1A5 (0.39) | SLC1A5POLBKMT2ATDP1SLC1A1 | |
| SCHEMBL7901687 | 0.75 | KMT2A (0.41) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL7901680 | 0.75 | KMT2A (0.41) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL7909588 | 0.73 | MAPT (0.40) | PKMSLC7A5POLBKMT2ATDP1 | |
| SCHEMBL7909596 | 0.73 | MAPT (0.40) | PKMSLC7A5POLBKMT2ATDP1 | |
| SCHEMBL6359011 | 0.71 | SLC1A1 (0.46) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL23656532 | 0.70 | FOLH1 (0.60) | ALPIPKMPTGS1XIAPSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207708-B1 | FOR THERAPY AND PROPHYLAXIS OF AUTOIMMUNE AND/OR INFLAMMATORY CONDITIONS AFFECTING THE JOINTS SUCH AS ARTHRITIS, AND INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, | G. D. SEARLE & COMPANY | 2001-03-27 | — | — | US | claimed |
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | claimed |
| WO-1997032844-A9 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | — | 1997-12-24 | — | — | WO | claimed |