Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.51 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.44 |
| ▸ | CPB2 | Q96IY4 | 9/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | GNPAT | O15228 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7909581 | 1.00 | FOLH1 (0.51) | FOLH1SLC6A5CPB2GSRCA1 | |
| SCHEMBL7172377 | 0.84 | FOLH1 (0.57) | FOLH1SLC6A5CPB2GSRCA1 | |
| SCHEMBL7172374 | 0.84 | FOLH1 (0.57) | FOLH1SLC6A5CPB2GSRCA1 | |
| Hydrochloric Acid SCHEMBL8709522 | 0.83 | FOLH1 (0.55) | FOLH1SLC6A5CPB2GSRCA1 | |
| SCHEMBL9295774 | 0.80 | FOLH1 (0.53) | FOLH1SLC6A5CPB2GSRCA1 | |
| SCHEMBL7225608 | 0.80 | MMP2 (0.45) | FOLH1SLC6A5CPB2CA1CA2 | |
| SCHEMBL7225611 | 0.80 | MMP2 (0.45) | FOLH1SLC6A5CPB2CA1CA2 | |
| SCHEMBL7232934 | 0.79 | FOLH1 (0.49) | FOLH1SLC6A5CPB2CA1CA2 | |
| SCHEMBL7232936 | 0.79 | FOLH1 (0.49) | FOLH1SLC6A5CPB2CA1CA2 | |
| Ethylene SCHEMBL28796153 | 0.79 | FOLH1 (0.58) | FOLH1SLC6A5CPB2GSRCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207708-B1 | FOR THERAPY AND PROPHYLAXIS OF AUTOIMMUNE AND/OR INFLAMMATORY CONDITIONS AFFECTING THE JOINTS SUCH AS ARTHRITIS, AND INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, | G. D. SEARLE & COMPANY | 2001-03-27 | — | — | US | disclosed |
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | disclosed |
| EP-0885188-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032844-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-09-12 | — | — | WO | disclosed |