SCHEMBL7910283

SCHEMBL7910283

CCCCCCc1ccccc1[Si](C)(Cl)Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LIPG Q9Y5X9 1/20 0.51
KCNH2 Q12809 1/20 0.43
NR1H2 P55055 1/20 0.43
NR1H3 Q13133 1/20 0.43
BID P55957 3/20 0.41
MCL1 Q07820 3/20 0.41
BCL2L1 Q07817 2/20 0.41
BAK1 Q16611 2/20 0.41
KAT8 Q9H7Z6 2/20 0.41
TLR8 Q9NR97 1/20 0.41
PPARG P37231 1/20 0.41
PPARA Q07869 1/20 0.41
EP300 Q09472 1/20 0.41
KAT2A Q92830 1/20 0.41
KAT2B Q92831 1/20 0.41
KAT5 Q92993 1/20 0.41
SAE1 Q9UBE0 1/20 0.41
THRA P10827 1/20 0.40
THRB P10828 1/20 0.40
CYSLTR2 Q9NS75 4/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29161558 0.87 LIPG (0.53) LIPGKCNH2NR1H2NR1H3BID
SCHEMBL28740159 0.85 LIPG (0.55) LIPGKCNH2NR1H2NR1H3BID
SCHEMBL1687091 0.80 LIPG (0.58) LIPGKCNH2NR1H2NR1H3BID
SCHEMBL1687032 0.80 LIPG (0.58) LIPGKCNH2NR1H2NR1H3BID
SCHEMBL1686485 0.80 LIPG (0.58) LIPGKCNH2NR1H2NR1H3BID
SCHEMBL1686748 0.80 LIPG (0.58) LIPGKCNH2NR1H2NR1H3BID
SCHEMBL1686687 0.80 LIPG (0.58) LIPGKCNH2NR1H2NR1H3BID
SCHEMBL1686411 0.80 LIPG (0.58) LIPGKCNH2NR1H2NR1H3BID
SCHEMBL1686606 0.80 LIPG (0.58) LIPGKCNH2NR1H2NR1H3BID
SCHEMBL16771452 0.80 LIPG (0.53) LIPGKCNH2NR1H2NR1H3BID

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20010054579-A1 METHOD OF SEPARATING DIFFERENT CHEMICALS IN A SAMPLE AHMED FAIZY (US) 2001-12-27 US disclosed
US-5993653-A POROUS PARTICLES HAVING A SURFACE, THE SURFACE OF SAID PARTICLES HAVING HEXYL-PHENYL BONDED THERETO, WHEREIN SAID POLMER-BASED CHROMATOBRAPHIC SUPPORT IS SILICA GEL. PHENOMENEX (US) 1999-11-30 US disclosed
EP-0903578-A2 A composition and column used in HPLC, a method for preparing the composition, and a method for separating different chemicals in a sample Phenomenex, Inc. (US) 1999-03-24 EP disclosed