Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 17/20 | 0.57 |
| ▸ | HTR6 | P50406 | 12/20 | 0.57 |
| ▸ | HTR2A | P28223 | 10/20 | 0.55 |
| ▸ | DRD2 | P14416 | 9/20 | 0.55 |
| ▸ | HTR1A | P08908 | 9/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL792446 | 0.98 | HTR7 (0.59) | HTR7HTR6HTR2ADRD2HTR1A | |
| SCHEMBL792815 | 0.97 | HTR7 (0.60) | HTR7HTR6HTR2ADRD2HTR1A | |
| SCHEMBL792477 | 0.95 | HTR7 (0.61) | HTR7HTR6HTR2ADRD2HTR1A | |
| SCHEMBL791492 | 0.91 | CCR1 (0.51) | HTR7HTR6HTR2ADRD2HTR1A | |
| SCHEMBL791286 | 0.89 | HTR7 (0.52) | HTR7HTR6HTR2ADRD2HTR1A | |
| SCHEMBL793456 | 0.87 | HTR7 (0.55) | HTR7HTR6HTR2ADRD2HTR1A | |
| SCHEMBL15064828 | 0.85 | HTR7 (0.56) | HTR7HTR6HTR2ADRD2HTR1A | |
| SCHEMBL792396 | 0.85 | HTR7 (0.54) | HTR7HTR6HTR2ADRD2HTR1A | |
| SCHEMBL791164 | 0.85 | HTR7 (0.59) | HTR7HTR6HTR2ADRD2HTR1A | |
| SCHEMBL792844 | 0.85 | HTR7 (0.49) | HTR7HTR6HTR2ADRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9120767-B2 | Arylosulfonamides for the treatment of CNS diseases | ADAMED SP. Z.O.O. (PL) | 2015-09-01 | — | — | US | disclosed |
| US-20140336200-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | ADAMED SP. Z O.O. (PL) | 2014-11-13 | — | — | US | disclosed |
| US-8822517-B2 | Arylosulfonamides for the treatment of CNS diseases | ADAMED SP. Z O.O. (PL) | 2014-09-02 | — | — | US | disclosed |
| EP-2616440-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | Adamed sp. z o.o. (PL) | 2013-07-24 | — | — | EP | disclosed |
| US-20130172365-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | ADAMED SP. Z.O.O. (PL) | 2013-07-04 | — | — | US | disclosed |
| WO-2012035123-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | ADAMED SP. Z O.O. (PL) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140336200-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | ARSA, PMP22, STS | HTR7 1419/4885HTR6 1131/4885HTR2A 1150/4885 |
| US-20130172365-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | ARSA, PMP22, STS | HTR7 1419/4885HTR6 1131/4885HTR2A 1150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.