Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 13/20 | 0.49 |
| ▸ | ITGB6 | P18564 | 7/20 | 0.43 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7910949 | 1.00 | ITGAV (0.49) | ITGAVITGB3ITGB6ITGB5 | |
| Hydrochloric Acid SCHEMBL7902241 | 0.87 | ITGB3 (0.56) | ITGAVITGB3ITGB5 | |
| Hydrochloric Acid SCHEMBL7902243 | 0.87 | ITGB3 (0.56) | ITGAVITGB3ITGB5 | |
| SCHEMBL7909673 | 0.86 | ITGAV (0.47) | ITGAVITGB3ITGB6ITGB5 | |
| SCHEMBL7909668 | 0.86 | ITGAV (0.47) | ITGAVITGB3ITGB6ITGB5 | |
| SCHEMBL7912505 | 0.82 | ITGB3 (0.61) | ITGAVITGB3 | |
| SCHEMBL8333656 | 0.77 | ITGAV (0.55) | ITGAVITGB3ITGB6 | |
| SCHEMBL5252354 | 0.77 | ITGAV (0.53) | ITGAVITGB3ITGB6ITGB5 | |
| SCHEMBL7909559 | 0.76 | ITGAV (0.53) | ITGAVITGB3ITGB6 | |
| SCHEMBL21317577 | 0.75 | ITGAV (0.48) | ITGAVITGB3ITGB6ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211184-B1 | TETRAHYDRO-PYRAZINE OR PYRIMIDINE DERIVATIVES; VITRONECTIN RECEPTOR ANTAGONIST; OSTEOPOROSIS; ANTIINFLAMMATORY, ANTITUMOR AGENTS; ANGIOGENESIS AND RESTENOSIS INHIBITORS | MERCK & CO., INC. | 2001-04-03 | — | — | US | disclosed |
| US-5981546-A | Integrin antagonists | MERCK & CO., INC. (US) | 1999-11-09 | — | — | US | disclosed |