Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8065389 | 0.95 | GRM5 (0.37) | PDE4BGRM5PDE4DHCRTR1HCRTR2 | |
| SCHEMBL3466221 | 0.87 | GRM5 (0.37) | PDE4BGRM5PDE4DHCRTR1HCRTR2 | |
| SCHEMBL3792867 | 0.87 | GRM5 (0.37) | PDE4BGRM5PDE4DHCRTR1HCRTR2 | |
| SCHEMBL13578424 | 0.87 | GRM5 (0.37) | PDE4BGRM5PDE4DHCRTR1HCRTR2 | |
| SCHEMBL13578423 | 0.87 | GRM5 (0.37) | PDE4BGRM5PDE4DHCRTR1HCRTR2 | |
| SCHEMBL3466246 | 0.87 | GRM5 (0.37) | PDE4BGRM5PDE4DHCRTR1HCRTR2 | |
| SCHEMBL4322265 | 0.86 | EGFR (0.39) | GRM5PDE4DHCRTR1HCRTR2SMN1; SMN2 | |
| SCHEMBL4322766 | 0.86 | EGFR (0.39) | GRM5PDE4DHCRTR1HCRTR2SMN1; SMN2 | |
| SCHEMBL3794589 | 0.86 | EGFR (0.39) | GRM5PDE4DHCRTR1HCRTR2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3790309 | 0.86 | EGFR (0.38) | GRM5PDE4DHCRTR1HCRTR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |