Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7911285 | 0.95 | PDE4B (0.37) | GRM5HCRTR1HCRTR2FFAR1PDE4B | |
| SCHEMBL3466926 | 0.88 | ITGB2 (0.40) | GRM5HCRTR1HCRTR2FFAR1 | |
| SCHEMBL3466742 | 0.88 | ITGB2 (0.40) | GRM5HCRTR1HCRTR2FFAR1 | |
| SCHEMBL3466737 | 0.88 | ITGB2 (0.40) | GRM5HCRTR1HCRTR2FFAR1 | |
| SCHEMBL13578422 | 0.87 | GRM5 (0.35) | GRM5HCRTR1HCRTR2FFAR1PDE4B | |
| SCHEMBL8066363 | 0.87 | HCRTR1 (0.37) | GRM5HCRTR1HCRTR2FFAR1PDE4B | |
| SCHEMBL3796897 | 0.87 | FPR2 (0.40) | GRM5HCRTR1HCRTR2FFAR1USP2 | |
| SCHEMBL3466119 | 0.87 | GRM5 (0.39) | GRM5HCRTR1HCRTR2FFAR1USP2 | |
| SCHEMBL3466121 | 0.87 | GRM5 (0.39) | GRM5HCRTR1HCRTR2FFAR1USP2 | |
| SCHEMBL3796904 | 0.87 | FPR2 (0.40) | GRM5HCRTR1HCRTR2FFAR1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |