SCHEMBL7912646

SCHEMBL7912646

O=C(O)CC(CO)C(CO)CC(=O)O

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC22A6 Q4U2R8 1/20 0.47
TDP1 Q9NUW8 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.43
GABRR1 P24046 2/20 0.39
LMNA P02545 2/20 0.39
TSHR P16473 1/20 0.39
OR51E2 Q9H255 1/20 0.38
FOLH1 Q04609 2/20 0.36
MAPT P10636 1/20 0.35
LDHA P00338 1/20 0.33
SRR Q9GZT4 1/20 0.33
ALKBH5 Q6P6C2 1/20 0.33
SUCNR1 Q9BXA5 1/20 0.33
EGLN1 Q9GZT9 1/20 0.33
MME P08473 2/20 0.32
CACNB3 P54284 1/20 0.32
CACNA2D1 P54289 1/20 0.32
CACNA1C Q13936 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9166426 0.83 SLC22A6 (0.39) SLC22A6TDP1SMN1; SMN2GABRR1LMNA
SCHEMBL21359895 0.83 SMN1; SMN2 (0.42) SLC22A6TDP1SMN1; SMN2GABRR1LMNA
SCHEMBL27043125 0.83 SLC22A6 (0.46) SLC22A6TDP1SMN1; SMN2GABRR1LMNA
SCHEMBL584099 0.82 SLC22A6 (0.56) SLC22A6TDP1SMN1; SMN2GABRR1LMNA
SCHEMBL29212181 0.79 SLC22A6 (0.48) SLC22A6TDP1SMN1; SMN2GABRR1LMNA
Ammonia Solution, Strong SCHEMBL22463070 0.79 TDP1 (0.59) SLC22A6TDP1SMN1; SMN2GABRR1LMNA
SCHEMBL45197 0.73
SCHEMBL619735 0.73 SLC22A6 (0.47) SLC22A6TDP1SMN1; SMN2GABRR1LMNA
SCHEMBL415845 0.71
SCHEMBL415844 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6207862-B1 PRECURSORS ARE CHIRAL 4-HYDROXYCARBOXAMIDES, 4-HYDROXYHYDROXAMIC ACIDS, OR 4-HYDROXYHYDRAZIDES PRODUCED FROM GAMMA-LACTONES, WHICH IN TURN ARE DERIVED FROM 1,4-DIOLS BY STEREOSELECTIVE OXIDATION, BIOCATALYTICS, INC. 2001-03-27 US disclosed
WO-1999032649-A1 METHODS AND PRECURSORS FOR THE PRODUCTION OF CHIRAL 1,3-AMINOALCOHOLS BIOCATALYTICS, INC. (US) 1999-07-01 WO disclosed
US-5916786-A Method for the production of chiral 1,3-aminoalcohols BIOCATALYTICS, INC. (US) 1999-06-29 US disclosed