Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | PDE5A | O76074 | 15/20 | 0.87 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.71 |
| ▸ | PDE2A | O00408 | 2/20 | 0.71 |
| ▸ | PDE9A | O76083 | 2/20 | 0.71 |
| ▸ | PDE4A | P27815 | 2/20 | 0.71 |
| ▸ | PDE6C | P51160 | 2/20 | 0.71 |
| ▸ | PDE1A | P54750 | 2/20 | 0.71 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.71 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.71 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.69 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.69 |
| ▸ | PDE6D | O43924 | 1/20 | 0.69 |
| ▸ | PDE8A | O60658 | 1/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13065357 | 0.96 | POLB (0.93) | POLBPDE5AKMT2AKDM4EPDE3B | |
| SCHEMBL13990518 | 0.96 | POLB (0.92) | POLBPDE5AKMT2AKDM4EPDE3B | |
| SCHEMBL13990482 | 0.95 | POLB (0.91) | POLBPDE5AKMT2AKDM4EPDE3B | |
| SCHEMBL13990470 | 0.94 | POLB (0.89) | POLBPDE5AKMT2AKDM4EPDE3B | |
| SCHEMBL8090115 | 0.94 | POLB (0.89) | POLBPDE5AKMT2AKDM4EPDE3B | |
| SCHEMBL13065808 | 0.94 | POLB (0.88) | POLBPDE5AKMT2AKDM4EPDE3B | |
| SCHEMBL13065810 | 0.93 | POLB (0.87) | POLBPDE5AKMT2AKDM4EPDE3B | |
| SCHEMBL13990498 | 0.93 | POLB (0.86) | POLBPDE5AKMT2AKDM4EPDE3B | |
| SCHEMBL13065922 | 0.92 | POLB (0.86) | POLBPDE5AKMT2AKDM4EPDE3B | |
| SCHEMBL13990511 | 0.92 | POLB (0.85) | POLBPDE5AKMT2AKDM4EPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318949-A1 | Pyrazolopyrimidinone Derivatives, Their Preparation And Their Use | TOPHARMAN SHANGHAI CO., LTD (CN) | 2008-12-25 | — | — | US | disclosed |
| US-20080318949-A1 | Pyrazolopyrimidinone Derivatives, Their Preparation And Their Use | TOPHARMAN SHANGHAI CO., LTD (CN) | 2008-12-25 | — | — | US | disclosed |
| US-6204383-B1 | REACTING SIDENAFIL PRECURSOR HAVING REACTIVE FUNCTIONALIZED HYDROXY WITH METHYLAMINE,TREATING REACTION AQUEOUS MEDIUM OF ACIDIC PH CAUSING PHASE SHIFT INTO THE AQUEOUS PHASE | TORCAN CHEMICAL LTD. (CA) | 2001-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318949-A1 | Pyrazolopyrimidinone Derivatives, Their Preparation And Their Use | PDE5A, PDE3A, PDE3B | POLB 2222/4885PDE5A 1/4885KMT2A 3136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.