Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.89 |
| ▸ | PDE5A | O76074 | 16/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.76 |
| ▸ | PDE6C | P51160 | 3/20 | 0.71 |
| ▸ | PDE2A | O00408 | 2/20 | 0.71 |
| ▸ | PDE9A | O76083 | 2/20 | 0.71 |
| ▸ | PDE4A | P27815 | 2/20 | 0.71 |
| ▸ | PDE1A | P54750 | 2/20 | 0.71 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.71 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.71 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.71 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.71 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.71 |
| ▸ | PDE6D | O43924 | 1/20 | 0.71 |
| ▸ | PDE8A | O60658 | 1/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | HTR1A | P08908 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16854873 | 0.94 | POLB (0.80) | POLBPDE5AKMT2AKDM4EPDE6C | |
| SCHEMBL7913058 | 0.94 | POLB (1.00) | POLBPDE5AKMT2AKDM4EPDE6C | |
| SCHEMBL13990518 | 0.94 | POLB (0.92) | POLBPDE5AKMT2AKDM4EPDE6C | |
| SCHEMBL7909595 | 0.92 | POLB (0.81) | POLBPDE5AKMT2AKDM4EPDE6C | |
| SCHEMBL13990475 | 0.91 | POLB (0.82) | POLBPDE5AKMT2AKDM4EPDE6C | |
| SCHEMBL13065357 | 0.91 | POLB (0.93) | POLBPDE5AKMT2AKDM4EPDE6C | |
| SCHEMBL13065925 | 0.90 | POLB (0.81) | POLBPDE5AKMT2AKDM4EPDE6C | |
| SCHEMBL13990482 | 0.90 | POLB (0.91) | POLBPDE5AKMT2AKDM4EPDE6C | |
| SCHEMBL13065922 | 0.90 | POLB (0.86) | POLBPDE5AKMT2AKDM4EPDE6C | |
| SCHEMBL8503688 | 0.90 | POLB (0.78) | POLBPDE5AKMT2AKDM4EPDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009000798-A1 | SILDENAFIL N-OXIDE AS PRODRUG | SOLVAY PHARMACEUTICALS B.V. (NL) | 2008-12-31 | — | — | WO | disclosed |