Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | CTSA | P10619 | 3/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4530340 | 0.93 | SCN9A (0.43) | PDE4DCNR2SCN9A | |
| SCHEMBL3465800 | 0.87 | PDE4D (0.42) | PDE4DCNR2CTSAHCRTR1HCRTR2 | |
| SCHEMBL3477920 | 0.86 | PDE4D (0.41) | PDE4DCNR2CTSAHCRTR1HCRTR2 | |
| SCHEMBL3791661 | 0.85 | PDE4D (0.44) | PDE4DCNR2CTSAHCRTR1HCRTR2 | |
| SCHEMBL3791280 | 0.84 | PDE4D (0.39) | PDE4DCNR2CTSAHCRTR1HCRTR2 | |
| SCHEMBL3467145 | 0.83 | CNR2 (0.41) | PDE4DCNR2CTSAHCRTR1HCRTR2 | |
| SCHEMBL3785842 | 0.83 | HTT (0.41) | PDE4DSCN9A | |
| SCHEMBL7913243 | 0.82 | CNR2 (0.41) | PDE4DCNR2CTSAHCRTR1HCRTR2 | |
| SCHEMBL7902765 | 0.80 | PDE4B (0.39) | PDE4DCTSAHCRTR1HCRTR2FBP1 | |
| SCHEMBL3467149 | 0.80 | PDE4D (0.43) | PDE4DHCRTR1HCRTR2FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2009067621-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |