Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | CTSA | P10619 | 6/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3791661 | 0.89 | PDE4D (0.44) | CNR2CNR1PDE4DCTSACD274 | |
| SCHEMBL3477920 | 0.88 | PDE4D (0.41) | CNR2CNR1PDE4DCTSACD274 | |
| SCHEMBL3465800 | 0.87 | PDE4D (0.42) | CNR2CNR1PDE4DCTSAFBP1 | |
| SCHEMBL3791280 | 0.86 | PDE4D (0.39) | CNR2CNR1PDE4DCTSACD274 | |
| SCHEMBL4530340 | 0.85 | SCN9A (0.43) | CNR2PDE4D | |
| SCHEMBL4323845 | 0.84 | PDE4B (0.37) | CNR2CNR1PDE4DCTSAHCRTR1 | |
| SCHEMBL8068411 | 0.83 | NR3C1 (0.38) | CNR2CNR1PDE4DCTSAHCRTR1 | |
| SCHEMBL7902765 | 0.82 | PDE4B (0.39) | PDE4DCTSAFBP1HCRTR1HCRTR2 | |
| SCHEMBL3467151 | 0.82 | PDE4B (0.39) | PDE4DPDE4B | |
| SCHEMBL7913060 | 0.82 | PDE4D (0.40) | CNR2CNR1PDE4DCTSACD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |