Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2378370 | 1.00 | REN (0.67) | RENKCNH2CYP3A4 | |
| SCHEMBL2378367 | 1.00 | REN (0.67) | RENKCNH2CYP3A4 | |
| SCHEMBL2378371 | 1.00 | REN (0.67) | RENKCNH2CYP3A4 | |
| SCHEMBL7909181 | 0.97 | REN (0.67) | RENKCNH2CYP3A4 | |
| SCHEMBL2376381 | 0.97 | REN (0.67) | RENKCNH2CYP3A4 | |
| SCHEMBL2376375 | 0.97 | REN (0.67) | RENKCNH2CYP3A4 | |
| SCHEMBL2376377 | 0.97 | REN (0.67) | RENKCNH2CYP3A4 | |
| SCHEMBL12243880 | 0.94 | REN (0.62) | RENKCNH2CYP3A4 | |
| SCHEMBL12243852 | 0.93 | REN (0.61) | RENKCNH2CYP3A4 | |
| SCHEMBL2376957 | 0.93 | REN (0.60) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010066028-A1 | 3,4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2010-06-17 | — | — | WO | disclosed |