Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.57 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7914440 | 0.91 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DSIRT2 | |
| SCHEMBL7916407 | 0.89 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7906213 | 0.86 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7913434 | 0.82 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7916316 | 0.82 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DPDE1C | |
| SCHEMBL7916353 | 0.81 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPDE1C | |
| SCHEMBL7906202 | 0.80 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6583531 | 0.80 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DSIRT2 | |
| SCHEMBL7914465 | 0.80 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7914395 | 0.79 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DSMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265402-B1 | ANTIINFLAMMATORY AGENTS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-07-24 | — | — | US | disclosed |
| EP-0924204-A1 | 2-PHENYLMORPHOLIN-5-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-06-23 | — | — | EP | disclosed |