Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PTAFR | P25105 | 8/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584193 | 0.89 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPTAFR | |
| SCHEMBL6582690 | 0.87 | PTAFR (0.48) | PDE4APDE4BPDE4CPDE4DPTAFR | |
| SCHEMBL6583051 | 0.85 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL6587870 | 0.83 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL6583522 | 0.82 | ACHE (0.45) | — | |
| SCHEMBL6583511 | 0.82 | PDE4B (0.44) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL6584131 | 0.81 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPTAFR | |
| SCHEMBL6585391 | 0.80 | ACHE (0.42) | PDE4APDE4BPDE4CPDE4DPTAFR | |
| SCHEMBL7913451 | 0.80 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DSIRT2 | |
| SCHEMBL11430072 | 0.80 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928789-B1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2004-09-29 | — | — | EP | disclosed |
| US-6251897-B1 | TREATING DERMATITIS, ASTHMA | NIKKEN CHEMICALS CO., LTD (JP) | 2001-06-26 | — | — | US | disclosed |
| EP-0928789-A1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-07-14 | — | — | EP | disclosed |