Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.50 |
| ▸ | MTOR | P42345 | 9/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.49 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.46 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.46 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1309827 | 0.90 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL1309312 | 0.82 | ROCK2 (0.52) | PIK3CAPIK3CDPIK3CGPIK3CBPARP1 | |
| SCHEMBL1309899 | 0.81 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL1310019 | 0.81 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL1310187 | 0.80 | PIK3CA (0.44) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL1311048 | 0.80 | PIK3CA (0.64) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL1312406 | 0.79 | PIK3CA (0.49) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL1310418 | 0.79 | PIK3CA (0.54) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL1310263 | 0.75 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR | |
| SCHEMBL1310334 | 0.75 | PIK3CA (0.60) | PIK3CAPIK3CDPIK3CGPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921361-B2 | Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes | UNIVERSITY OF BASEL (CH) | 2014-12-30 | — | — | US | disclosed |
| US-8921361-B2 | Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes | UNIVERSITY OF BASEL (CH) | 2014-12-30 | — | — | US | disclosed |
| US-20110275762-A1 | TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2011-11-10 | — | — | US | disclosed |
| US-20110275762-A1 | TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2011-11-10 | — | — | US | disclosed |
| WO-2010052569-A2 | TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275762-A1 | TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | MTOR, PIK3CA, PIK3CD | PIK3CA 2/4885PIK3CD 3/4885PIK3CG 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.