⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30782476 | 1.00 | — | — | |
| SCHEMBL17061707 | 1.00 | — | — | |
| SCHEMBL2297929 | 1.00 | — | — | |
| SCHEMBL2924066 | 1.00 | — | — | |
| SCHEMBL2924068 | 1.00 | — | — | |
| SCHEMBL25040954 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL14880473 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL14880475 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL16198457 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL31404651 | 0.97 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4198017-A1 | BENZYLAMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | Academy of Military Medical Sciences (CN) | 2023-06-21 | — | — | EP | disclosed |
| WO-2022111621-A1 | AMINOHETEROARYL KINASE INHIBITORS | ANRUI BIOMEDICAL TECHNOLOGY (GUANGZHOU) CO., LTD. (CN) | 2022-06-02 | — | — | WO | disclosed |
| WO-2022033303-A1 | BENZYLAMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | 中国人民解放军军事科学院军事医学研究院 | 2022-02-17 | — | — | WO | disclosed |
| US-20180370973-A1 | FUSED HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-12-27 | — | — | US | disclosed |
| US-10010539-B2 | Pyrazole, triazole and tetrazole orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2018-07-03 | — | — | US | disclosed |
| US-9988351-B2 | Method for producing 5-hydroxypiperidine-2-carboxylic acid | API CORPORATION (JP) | 2018-06-05 | — | — | US | disclosed |
| US-20180002286-A1 | METHOD FOR PRODUCING 5-HYDROXYPIPERIDINE-2-CARBOXYLIC ACID | API CORPORATION (JP) | 2018-01-04 | — | — | US | disclosed |
| US-20170319560-A1 | PYRAZOLE, TRIAZOLE AND TETRAZOLE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-11-09 | — | — | US | disclosed |
| US-20170319560-A1 | PYRAZOLE, TRIAZOLE AND TETRAZOLE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-11-09 | — | — | US | disclosed |
| US-9790181-B2 | Method for producing 5-hydroxypiperidine-2-carboxylic acid | API CORPORATION (JP) | 2017-10-17 | — | — | US | disclosed |
| WO-2014137883-A1 | 2-PYRIDYLOXY-4-ETHER OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2014-09-12 | — | — | WO | disclosed |
| WO-2014099698-A1 | 2-PYRIDYLOXY-3-NITRILE-4-SUBSTITUTED OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014099698-A1 | 2-PYRIDYLOXY-3-NITRILE-4-SUBSTITUTED OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014066196-A1 | 2-PYRIDYLOXY-3-SUBSTITUTED-4-NITRILE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2014-05-01 | — | — | WO | disclosed |
| WO-2014066196-A1 | 2-PYRIDYLOXY-3-SUBSTITUTED-4-NITRILE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2014-05-01 | — | — | WO | disclosed |
| US-8710076-B2 | 2,5-disubstituted piperidine orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-04-29 | — | — | US | disclosed |
| US-8710076-B2 | 2,5-disubstituted piperidine orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-04-29 | — | — | US | disclosed |
| US-20110201632-A1 | 2,5-Disubstituted Piperidine Orexin Rceptor Antagonists | MERCK SHARP & DOHME LLC | 2011-08-18 | — | — | US | disclosed |
| US-20110201632-A1 | 2,5-Disubstituted Piperidine Orexin Rceptor Antagonists | MERCK SHARP & DOHME LLC | 2011-08-18 | — | — | US | disclosed |
| WO-2010048012-A1 | 2,5-DISUBSTITUTED PIPERIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2010-04-29 | — | — | WO | disclosed |