Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 5/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.71 |
| ▸ | HTR2C | P28335 | 2/20 | 0.71 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.71 |
| ▸ | DRD3 | P35462 | 2/20 | 0.71 |
| ▸ | MLNR | O43193 | 1/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.71 |
| ▸ | DRD2 | P14416 | 1/20 | 0.71 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.71 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.71 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.71 |
| ▸ | HRH1 | P35367 | 1/20 | 0.71 |
| ▸ | MC3R | P41968 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784909 | 1.00 | CASR (0.71) | CASRSLC6A4ADRA2CSLC6A2HTR2C | |
| SCHEMBL14036495 | 0.86 | CASR (0.73) | CASRSLC6A4ADRA2CSLC6A2HTR2C | |
| SCHEMBL13889779 | 0.86 | CASR (0.73) | CASRSLC6A4ADRA2CSLC6A2HTR2C | |
| SCHEMBL6223352 | 0.86 | CASR (0.71) | CASRSLC6A4ADRA2CSLC6A2HTR2C | |
| SCHEMBL6868490 | 0.85 | CASR (0.71) | CASRSLC6A4ADRA2CSLC6A2HTR2C | |
| SCHEMBL7895914 | 0.85 | CASR (0.71) | CASRSLC6A4ADRA2CSLC6A2HTR2C | |
| Cinacalcet SCHEMBL30371982 | 0.83 | CASR (1.00) | CASRSLC6A4ADRA2CSLC6A2HTR2C | |
| Cinacalcet SCHEMBL29360301 | 0.83 | CASR (1.00) | CASRSLC6A4ADRA2CSLC6A2HTR2C | |
| Cinacalcet SCHEMBL3227084 | 0.83 | CASR (1.00) | CASRSLC6A4ADRA2CSLC6A2HTR2C | |
| Cinacalcet SCHEMBL71876 | 0.83 | CASR (1.00) | CASRSLC6A4ADRA2CSLC6A2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112374999-A | Preparation method of impurity compound for defluorination of cinacalcet hydrochloride | 福安药业集团重庆礼邦药物开发有限公司 | 2021-02-19 | — | — | CN | disclosed |
| WO-2016151295-A1 | FLUORINATION PROCESS | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2016-09-29 | — | — | WO | disclosed |
| EP-2403823-B1 | PROCESS FOR THE PREPARATION OF CINACALCET AND SALTS THEREOF, AND INTERMEDIATES FOR USE IN THE PROCESS | CIPLA LTD (IN) | 2015-10-21 | — | — | EP | disclosed |
| US-8575393-B2 | Process for the preparation of cinacalcet and salts thereof, and intermediates for use in the process | CIPLA LIMITED (IN) | 2013-11-05 | — | — | US | disclosed |
| US-20120053362-A1 | Process for the Preparation of Cinacalcet and Salts Thereof, and Intermediates for Use in the Process | CIPLA LIMITED (IN) | 2012-03-01 | — | — | US | disclosed |
| WO-2010100429-A1 | PROCESS FOR THE PREPARATION OF CINACALCET AND SALTS THEREOF, AND INTERMEDIATES FOR USE IN THE PROCESS | CIPLA LIMITED (IN) | 2010-09-10 | — | — | WO | disclosed |
| WO-2008058236-A2 | METHODS FOR PREPARING CINACALCET HYDROCHLORIDE | DR. REDDY'S LABORTORIES, LTD. (IN) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053362-A1 | Process for the Preparation of Cinacalcet and Salts Thereof, and Intermediates for Use in the Process | CA4, CA9, SLC28A1 | CASR 34/4885SLC6A4 89/4885ADRA2C 335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.