Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 4/20 | 0.71 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.71 |
| ▸ | HTR2C | P28335 | 2/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.71 |
| ▸ | DRD3 | P35462 | 2/20 | 0.71 |
| ▸ | MLNR | O43193 | 1/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.71 |
| ▸ | DRD2 | P14416 | 1/20 | 0.71 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.71 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.71 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.71 |
| ▸ | HRH1 | P35367 | 1/20 | 0.71 |
| ▸ | MC3R | P41968 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223352 | 0.88 | CASR (0.71) | CASROPRM1ADRA2CSLC6A2HTR2C | |
| SCHEMBL7895914 | 0.87 | CASR (0.71) | CASROPRM1ADRA2CSLC6A2HTR2C | |
| SCHEMBL15131013 | 0.87 | CASR (0.63) | CASROPRM1ADRA2CSLC6A2HTR2C | |
| SCHEMBL14036495 | 0.86 | CASR (0.73) | CASROPRM1ADRA2CSLC6A2HTR2C | |
| SCHEMBL13889779 | 0.86 | CASR (0.73) | CASROPRM1ADRA2CSLC6A2HTR2C | |
| SCHEMBL4784909 | 0.85 | CASR (0.71) | CASROPRM1ADRA2CSLC6A2HTR2C | |
| SCHEMBL7914573 | 0.85 | CASR (0.71) | CASROPRM1ADRA2CSLC6A2HTR2C | |
| SCHEMBL6221382 | 0.84 | CASR (0.66) | CASROPRM1ADRA2CSLC6A2HTR2C | |
| SCHEMBL15131057 | 0.83 | CASR (0.59) | CASROPRM1ADRA2CSLC6A2HTR2C | |
| Cinacalcet SCHEMBL71876 | 0.83 | CASR (1.00) | CASROPRM1ADRA2CSLC6A2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180055856-A1 | COMBINATION OF LOW DOSE 2-METHYLENE-19-NOR-(20S)-1ALPHA, 25-DIHYDROXYVITAMIN D3 AND CALCIMIMETICS TO TREAT SECONDARY HYPERPARATHYROIDISM | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2018-03-01 | — | — | US | disclosed |
| US-20150152040-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | AMNEAL PHARMACEUTICALS LLC (US) | 2015-06-04 | — | — | US | disclosed |
| US-20150152040-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | AMNEAL PHARMACEUTICALS LLC (US) | 2015-06-04 | — | — | US | disclosed |
| US-20150152040-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | AMNEAL PHARMACEUTICALS LLC (US) | 2015-06-04 | — | — | US | disclosed |
| US-8969623-B2 | Method for the preparation of cinacalcet and intermediates and impurities thereof | Amneal Pharmaceuticals, LLC (US) | 2015-03-03 | — | — | US | disclosed |
| US-8969623-B2 | Method for the preparation of cinacalcet and intermediates and impurities thereof | Amneal Pharmaceuticals, LLC (US) | 2015-03-03 | — | — | US | disclosed |
| US-8969623-B2 | Method for the preparation of cinacalcet and intermediates and impurities thereof | Amneal Pharmaceuticals, LLC (US) | 2015-03-03 | — | — | US | disclosed |
| US-8759586-B2 | Processes for the preparation of cinacalcet | RANBAXY LABORATORIES LIMITED (IN) | 2014-06-24 | — | — | US | disclosed |
| US-20140081048-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | MEGAFINE PHARMA (P) LTD. (IN) | 2014-03-20 | — | — | US | disclosed |
| US-20140081048-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | MEGAFINE PHARMA (P) LTD. (IN) | 2014-03-20 | — | — | US | disclosed |
| US-20120309842-A1 | PROCESSES FOR THE PREPARATION OF CINACALCET | RANBAXY LABORATORIES LIMITED (IN) | 2012-12-06 | — | — | US | disclosed |
| US-20110319663-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | Amneal Pharmaceuticals, LLC (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110319663-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | Amneal Pharmaceuticals, LLC (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110319663-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | Amneal Pharmaceuticals, LLC (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110189241-A1 | Process For Controlling The Particle Size of A [3-(Trifluoromethyl)Phenyl]-1-Aminopropane Derivative | MEDICHEM, S.A. (ES) | 2011-08-04 | — | — | US | disclosed |
| WO-2011056325-A2 | OLIGOMER-CALCIMIMETIC CONJUGATES AND RELATED COMPOUNDS | NEKTAR THERAPEUTICS (US) | 2011-05-12 | — | — | WO | disclosed |
| WO-2011029833-A1 | PROCESS FOR PREPARING CINACALCET | ZACH SYSTEM S.P.A. (IT) | 2011-03-17 | — | — | WO | disclosed |
| US-20100267988-A1 | PROCESSES FOR PREPARING INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF CINACALCET | MEDICHEM, S.A. (ES) | 2010-10-21 | — | — | US | disclosed |
| WO-2010004588-A2 | PROCESS FOR PREPARING CINACALCET AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | IND-SWIFT LABORATORIES LIMITED (IN) | 2010-01-14 | — | — | WO | disclosed |
| US-7368606-B2 | Amorphous cinacalcet hydrochloride and preparation thereof | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180055856-A1 | COMBINATION OF LOW DOSE 2-METHYLENE-19-NOR-(20S)-1ALPHA, 25-DIHYDROXYVITAMIN D3 AND CALCIMIMETICS TO TREAT SECONDARY HYPERPARATHYROIDISM | PTH1R, CYP24A1, VDR | CASR 41/4885OPRM1 1865/4885ADRA2C 84/4885 |
| US-20110189241-A1 | Process For Controlling The Particle Size of A [3-(Trifluoromethyl)Phenyl]-1-Aminopropane Derivative | PKD1, CLTC, NPEPPS | CASR 1085/4885OPRM1 3311/4885ADRA2C 1762/4885 |
| US-20110319663-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | CMA1, SI, ALDH1A1 | CASR 1464/4885OPRM1 737/4885ADRA2C 267/4885 |
| US-20120309842-A1 | PROCESSES FOR THE PREPARATION OF CINACALCET | CA4, SI, CA9 | CASR 147/4885OPRM1 3913/4885ADRA2C 1904/4885 |
| US-20140081048-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | CMA1, SI, ALDH1A1 | CASR 1464/4885OPRM1 737/4885ADRA2C 267/4885 |
| US-20150152040-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | CMA1, SI, ALDH1A1 | CASR 1464/4885OPRM1 737/4885ADRA2C 267/4885 |
| US-20100267988-A1 | PROCESSES FOR PREPARING INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF CINACALCET | SI, KRAS, PREP | CASR 1772/4885OPRM1 3343/4885ADRA2C 2661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.