Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.33 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2221417 | 1.00 | MAPT (0.44) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL2221420 | 1.00 | MAPT (0.44) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL16421121 | 0.94 | MAPT (0.47) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL16418495 | 0.94 | MAPT (0.47) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL10965572 | 0.87 | MEN1 (0.37) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL12549290 | 0.83 | MAPT (0.46) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL16421155 | 0.81 | MAPT (0.44) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL28448339 | 0.81 | MAPT (0.44) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL6883354 | 0.81 | MAPT (0.44) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL1952608 | 0.81 | MAPT (0.44) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010088394-A1 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-08-05 | — | — | WO | disclosed |