Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28404374 | 0.98 | USP2 (0.42) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL29277716 | 0.94 | CA2 (0.43) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL23834436 | 0.89 | TSHR (0.48) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL16421155 | 0.88 | MAPT (0.44) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL23833875 | 0.86 | TSHR (0.44) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL16418495 | 0.84 | MAPT (0.47) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL3124113 | 0.84 | CPB2 (0.47) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL16421121 | 0.84 | MAPT (0.47) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL3125182 | 0.84 | CPB2 (0.47) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL3119914 | 0.84 | CA1 (0.61) | MAPTUSP2ALDH1A1CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116997551-A | Synthesis of EGFR modulators | 密歇根大学董事会 | 2023-11-03 | — | — | CN | disclosed |
| CN-116783202-A | Thienopyrrole compounds | 吉利德科学公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-115260195-B | EGFR degrading agent | 上海齐鲁制药研究中心有限公司 | 2023-07-04 | — | — | CN | disclosed |
| CN-115894489-A | Inhibitor of receptor interaction protein kinase 1, preparation method and application thereof | 中国药科大学 | 2023-04-04 | — | — | CN | disclosed |
| CN-115260195-A | EGFR degradation agent | 上海齐鲁制药研究中心有限公司 | 2022-11-01 | — | — | CN | disclosed |
| CN-112625028-A | Compounds and compositions for inhibiting SHP2 activity | 诺华股份有限公司 | 2021-04-09 | — | — | CN | disclosed |
| CN-107922388-B | Compounds and compositions for inhibiting SHP2 activity | 诺华股份有限公司 | 2020-12-29 | — | — | CN | disclosed |
| CN-111886009-A | EGFR dimer disruptors and uses thereof | 密歇根大学董事会 | 2020-11-03 | — | — | CN | disclosed |
| CN-107787323-B | Compounds and compositions for inhibiting SHP2 activity | 诺华股份有限公司 | 2020-09-01 | — | — | CN | disclosed |