Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2501874 | 0.87 | PDE10A (0.71) | PDE10AALDH1A1 | |
| SCHEMBL2750597 | 0.86 | PDE10A (0.70) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2472403 | 0.86 | PDE10A (0.70) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3506103 | 0.85 | PDE10A (0.78) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3504464 | 0.85 | PDE10A (0.78) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3505967 | 0.85 | PDE10A (1.00) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2503777 | 0.84 | PDE10A (0.73) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2480986 | 0.83 | PDE10A (0.66) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7911573 | 0.83 | PDE10A (0.65) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7911641 | 0.82 | PDE10A (0.68) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063610-A1 | PYRIDAZINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-10 | — | — | WO | disclosed |