Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4794862 | 0.98 | HRH3 (0.50) | PDE8BHRH3OPRD1KDM1A | |
| SCHEMBL5218137 | 0.97 | PDE8B (0.48) | PDE8BHRH3 | |
| SCHEMBL5218145 | 0.97 | PDE8B (0.48) | PDE8BHRH3 | |
| SCHEMBL7915142 | 0.95 | HRH3 (0.50) | PDE8BHRH3 | |
| SCHEMBL4714199 | 0.95 | HRH3 (0.50) | PDE8BHRH3 | |
| SCHEMBL4714197 | 0.95 | HRH3 (0.50) | PDE8BHRH3 | |
| SCHEMBL18461803 | 0.87 | PDE8B (0.43) | PDE8BHRH3OPRD1ATM | |
| SCHEMBL4719547 | 0.86 | SMN1; SMN2 (0.48) | PDE8BHRH3ATM | |
| SCHEMBL6304018 | 0.86 | SMN1; SMN2 (0.48) | PDE8BHRH3ATM | |
| SCHEMBL4719550 | 0.86 | SMN1; SMN2 (0.48) | PDE8BHRH3ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221865-B1 | INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND PROTEIN GERANYLGERANYLTRANSFERASE. | UNIVERSITY OF PITTSBURGH | 2001-04-24 | — | — | US | disclosed |