Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.50 |
| ▸ | PDE8B | O95263 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4714197 | 1.00 | HRH3 (0.50) | HRH3PDE8BKCNH2HSD17B10HPGD | |
| SCHEMBL4714199 | 1.00 | HRH3 (0.50) | HRH3PDE8BKCNH2HSD17B10HPGD | |
| SCHEMBL5218145 | 0.98 | PDE8B (0.48) | HRH3PDE8BKCNH2HSD17B10SMN1; SMN2 | |
| SCHEMBL5218137 | 0.98 | PDE8B (0.48) | HRH3PDE8BKCNH2HSD17B10SMN1; SMN2 | |
| SCHEMBL4794862 | 0.97 | HRH3 (0.50) | HRH3PDE8BHPGD | |
| SCHEMBL7915136 | 0.95 | PDE8B (0.51) | HRH3PDE8B | |
| SCHEMBL18461803 | 0.89 | PDE8B (0.43) | HRH3PDE8BKCNH2HSD17B10SMN1; SMN2 | |
| SCHEMBL4719547 | 0.87 | SMN1; SMN2 (0.48) | HRH3PDE8BHSD17B10SMN1; SMN2 | |
| SCHEMBL4719550 | 0.87 | SMN1; SMN2 (0.48) | HRH3PDE8BHSD17B10SMN1; SMN2 | |
| SCHEMBL6304018 | 0.87 | SMN1; SMN2 (0.48) | HRH3PDE8BHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221865-B1 | INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND PROTEIN GERANYLGERANYLTRANSFERASE. | UNIVERSITY OF PITTSBURGH | 2001-04-24 | — | — | US | disclosed |