Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7916056 | 0.97 | PDE4B (0.57) | PDE4BNFKB1BLMPMP22PARP15 | |
| SCHEMBL30352570 | 0.95 | PDE4B (0.63) | PDE4BNFKB1BLMPMP22PDE4A | |
| SCHEMBL7913450 | 0.95 | PDE4B (0.63) | PDE4BNFKB1BLMPMP22PDE4A | |
| SCHEMBL6582595 | 0.85 | PDE4B (0.55) | PDE4BPARP15PARP10PDE4APDE4C | |
| SCHEMBL6585923 | 0.82 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7913418 | 0.82 | PDE4A (0.59) | PDE4BNFKB1BLMPMP22PDE4A | |
| SCHEMBL7915754 | 0.81 | PDE4A (0.58) | PDE4BNFKB1BLMPMP22PDE4A | |
| SCHEMBL15921910 | 0.80 | NFKB1 (0.75) | NFKB1BLMPMP22ADRA2AADRA1A | |
| SCHEMBL29633151 | 0.80 | NFKB1 (0.75) | NFKB1BLMPMP22ADRA2AADRA1A | |
| SCHEMBL1966507 | 0.80 | NFKB1 (0.75) | NFKB1BLMPMP22ADRA2AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265402-B1 | ANTIINFLAMMATORY AGENTS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-07-24 | — | — | US | disclosed |
| EP-0924204-A1 | 2-PHENYLMORPHOLIN-5-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-06-23 | — | — | EP | disclosed |