Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.77 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.73 |
| ▸ | CTSD | P07339 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12391207 | 0.89 | BACE1 (0.71) | BACE1BACE2CTSD | |
| SCHEMBL7927041 | 0.88 | BACE1 (0.66) | BACE1BACE2CTSD | |
| SCHEMBL7918277 | 0.87 | BACE1 (1.00) | BACE1BACE2CTSD | |
| SCHEMBL9913117 | 0.87 | BACE1 (1.00) | BACE1BACE2CTSD | |
| SCHEMBL12558207 | 0.87 | BACE1 (0.76) | BACE1BACE2CTSD | |
| SCHEMBL1935932 | 0.86 | BACE1 (0.73) | BACE1BACE2 | |
| SCHEMBL7916643 | 0.85 | BACE1 (0.72) | BACE1BACE2CTSD | |
| SCHEMBL9913118 | 0.84 | BACE1 (0.71) | BACE1BACE2CTSD | |
| SCHEMBL15630354 | 0.84 | BACE1 (1.00) | BACE1BACE2CTSD | |
| SCHEMBL3299384 | 0.83 | BACE1 (0.54) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038686-A1 | NOVEL FUSED AMINODIHYDROTHIAZINE DERIVATIVE | エーザイ・アール・アンド・ディー・マネジメント株式会社 (JP) | 2010-04-08 | — | — | WO | disclosed |